A family copes with a sick daughter and a dying son, and the team must diagnose the daughter before its too late. Meanwhile, House deals with an elderly father and son, and tries to deal with the challenges of a workplace romance.

After a 200-year-old medicine jar found on an off-shore shipwreck shatters in a teenage girl’s palm, she is admitted to Princeton Plainsboro for symptoms closely linked to smallpox. When the Center for Disease Control’s Dr. Dave Broda institutes a lockdown on the hospital and suspends House’s team’s ability to diagnose, Masters grows suspicious of Broda’s motives and becomes convinced that the patient is suffering from a different disease. The girl’s father soon experiences similar symptoms, and House is forced to make a precarious decision that puts his own life in jeopardy. Meanwhile, Wilson and Sam comfort a 6-year-old chemotherapy patient who prompts them to examine their relationship.

Sir David Attenborough tells the stories of the world's best animal architects. There are house-proud bower birds, who only find a mate if they decorate their homes perfectly. There are hornets, who build electric central-heating systems, and the star-nosed mole whose house is so well designed that his favourite meal of worms literally drop in for dinner. From larders to nurseries and from high-rises to subway systems, Attenborough shows that the animal architects have designed it way before we humans.

Sir David Attenborough tells the stories of the world's best animal architects. There are house-proud bower birds, who only find a mate if they decorate their homes perfectly. There are hornets, who build electric central-heating systems, and the star-nosed mole whose house is so well designed that his favourite meal of worms literally drop in for dinner. From larders to nurseries and from high-rises to subway systems, Attenborough shows that the animal architects have designed it way before we humans.